PPIRE17801
Target Protein Information
| Protein_Name | Ancillary SecYEG translocon subunit |
|---|---|
| Protein_Sequence | MEIYENENDQVEAVKRFFAENGKALAVGVILGVGALIGWRYWNSHQVDSARSASLAYQNAVTAVSEGKPDSIPAAEKFAAENKNTYGALASLELAQQFVDKNELEKAAAQLQQGLADTSDENLKAVINLRLARVQVQLKQADAALKTLDTIKGEGWAAIVADLRGEALLSKGDKQGARSAWEAGVKSDVTPALSEMMQMKINNLSI |
| Organism_Source | Escherichia coli (strain K12) |
| Functional_Classification | Protein conducting channels SecYEG translocon ancillary subunits |
| Cellular_Localization | Plasma membrane |
| Gene_Names | yfgM |
| UniProt_ID | P76576 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | LamB signal peptide |
|---|---|
| Peptide_Sequence | XMXXLXXXXXXXAXXXGXXXXXXXX |
| Peptide_Length | 25 |
| Peptide_SMILES | CSCC[C@H](NC(=O)CN)C(=O)NCC(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
|
|
|
Peptide Physicochemical
| Molecular_Weight | 1588.59 |
|---|---|
| Aliphatic_Index | 19.60000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 2.16000 |
| Charge_at_pH_7 | -0.00202 |
| Isoelectric_Point | 6.10000 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 27 |
| Number_of_Hydrogen_Bond_Donors | 26 |
| Topological_Polar_Surface_Area | 761.72000 |
| X_logP_energy | -19.25660 |
Interaction Information
| Affinity | KD=10 uM |
|---|---|
| Affinity_Assay | binding assay |
| PDB_ID | None |
| Type | Substrate |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Dynamic Nuclear Polarization-Enhanced Solid-State NMR of a 13C-Labeled Signal Peptide Bound to Lipid-Reconstituted Sec Translocon |
| Release_Year | 2011 |
| PMID | 22040139 |
| DOI | 10.1021/ja209378h |