PPIRE17804

Target Protein Information
Protein_Name Virulence-associated V antigen
Protein_Sequence MIRAYEQNPQHFIEDLEKVRVEQLTGHGSSVLEELVQLVKDKNIDISIKYDPRKDSEVFANRVITDDIELLKKILAYFLPEDAILKGGHYDNQLQNGIKRVKEFLESSPNTQWELRAFMAVMHFSLTADRIDDDILKVIVDSMNHHGDARSKLREELAELTAELKIYSVIQAEINKHLSSSGTINIHDKSINLMDKNLYGYTDEEIFKASAEYKILEKMPQTTIQVDGSEKKIVSIKDFLGSENKRTGALGNLKNSYSYNKDNNELSHFATTCSDKSRPLNDLVSQKTTQLSDITSRFNSAIEALNRFIQKYDSVMQRLLDDTSGK
Organism_Source Yersinia pestis
Functional_Classification Bacterial toxins V antigen pore forming modulator
Cellular_Localization Extracellular
Gene_Names lcrV
UniProt_ID P0C7U7
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Peptide f
Peptide_Sequence GSENKRTGALGNLKN
Peptide_Length 15
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)CN)[C@@H](C)O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1558.71
Aliphatic_Index 58.66667
Aromaticity 0.00000
Average_Rotatable_Bonds 3.73333
Charge_at_pH_7 1.99917
Isoelectric_Point 10.78901
Number_of_Hydrogen_Bond_Acceptors 25
Number_of_Hydrogen_Bond_Donors 27
Topological_Polar_Surface_Area 791.69000
X_logP_energy -12.42283
Interaction Information
Affinity IC50=16 uM
Affinity_Assay ELISA
PDB_ID 1R6F
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Identifying B and T cell epitopes and studying humoral mucosal and cellular immune responses of peptides derived from V antigen of Yersinia pestis
Release_Year 2008
PMID 18096277
DOI 10.1016/j.vaccine.2007.11.028