PPIRE17805

Target Protein Information
Protein_Name Virulence-associated V antigen
Protein_Sequence MIRAYEQNPQHFIEDLEKVRVEQLTGHGSSVLEELVQLVKDKNIDISIKYDPRKDSEVFANRVITDDIELLKKILAYFLPEDAILKGGHYDNQLQNGIKRVKEFLESSPNTQWELRAFMAVMHFSLTADRIDDDILKVIVDSMNHHGDARSKLREELAELTAELKIYSVIQAEINKHLSSSGTINIHDKSINLMDKNLYGYTDEEIFKASAEYKILEKMPQTTIQVDGSEKKIVSIKDFLGSENKRTGALGNLKNSYSYNKDNNELSHFATTCSDKSRPLNDLVSQKTTQLSDITSRFNSAIEALNRFIQKYDSVMQRLLDDTSGK
Organism_Source Yersinia pestis
Functional_Classification Bacterial toxins V antigen pore forming modulator
Cellular_Localization Extracellular
Gene_Names lcrV
UniProt_ID P0C7U7
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Peptide g
Peptide_Sequence SYSYNKDNNELSHFA
Peptide_Length 15
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1788.85
Aliphatic_Index 32.66667
Aromaticity 0.20000
Average_Rotatable_Bonds 3.80000
Charge_at_pH_7 -0.91088
Isoelectric_Point 5.45417
Number_of_Hydrogen_Bond_Acceptors 28
Number_of_Hydrogen_Bond_Donors 28
Topological_Polar_Surface_Area 830.44000
X_logP_energy -10.57180
Interaction Information
Affinity IC50=16 uM
Affinity_Assay ELISA
PDB_ID 1R6F
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Identifying B and T cell epitopes and studying humoral mucosal and cellular immune responses of peptides derived from V antigen of Yersinia pestis
Release_Year 2008
PMID 18096277
DOI 10.1016/j.vaccine.2007.11.028