PPIRE17807

Target Protein Information
Protein_Name Virulence-associated V antigen
Protein_Sequence MIRAYEQNPQHFIEDLEKVRVEQLTGHGSSVLEELVQLVKDKNIDISIKYDPRKDSEVFANRVITDDIELLKKILAYFLPEDAILKGGHYDNQLQNGIKRVKEFLESSPNTQWELRAFMAVMHFSLTADRIDDDILKVIVDSMNHHGDARSKLREELAELTAELKIYSVIQAEINKHLSSSGTINIHDKSINLMDKNLYGYTDEEIFKASAEYKILEKMPQTTIQVDGSEKKIVSIKDFLGSENKRTGALGNLKNSYSYNKDNNELSHFATTCSDKSRPLNDLVSQKTTQLSDITSRFNSAIEALNRFIQKYDSVMQRLLDDTSGK
Organism_Source Yersinia pestis
Functional_Classification Bacterial toxins V antigen pore forming modulator
Cellular_Localization Extracellular
Gene_Names lcrV
UniProt_ID P0C7U7
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Peptide j
Peptide_Sequence DIELLKKILAGGFIQKYDSVMQ
Peptide_Length 22
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)O)C(C)C)[C@@H](C)CC
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2509.99
Aliphatic_Index 124.09091
Aromaticity 0.09091
Average_Rotatable_Bonds 4.04545
Charge_at_pH_7 -0.00108
Isoelectric_Point 6.54619
Number_of_Hydrogen_Bond_Acceptors 34
Number_of_Hydrogen_Bond_Donors 33
Topological_Polar_Surface_Area 991.02000
X_logP_energy -5.53700
Interaction Information
Affinity IC50=32 uM
Affinity_Assay ELISA
PDB_ID 1R6F
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Identifying B and T cell epitopes and studying humoral mucosal and cellular immune responses of peptides derived from V antigen of Yersinia pestis
Release_Year 2008
PMID 18096277
DOI 10.1016/j.vaccine.2007.11.028