PPIRE17871

Target Protein Information
Protein_Name Plasmid partition protein A
Protein_Sequence MSDSSQLHKVAQRANRMLNVLTEQVQLQKDELHANEFYQVYAKAALAKLPLLTRANVDYAVSEMEEKGYVFDKRPAGSSMKYAMSIQNIIDIYEHRGVPKYRDRYSEAYVIFISNLKGGVSKTVSTVSLAHAMRAHPHLLMEDLRILVIDLDPQSSATMFLSHKHSIGIVNATSAQAMLQNVSREELLEEFIVPSVVPGVDVMPASIDDAFIASDWRELCNEHLPGQNIHAVLKENVIDKLKSDYDFILVDSGPHLDAFLKNALASANILFTPLPPATVDFHSSLKYVARLPELVKLISDEGCECQLATNIGFMSKLSNKADHKYCHSLAKEVFGGDMLDVFLPRLDGFERCGESFDTVISANPATYVGSADALKNARIAAEDFAKAVFDRIEFIRSN
Organism_Source Escherichia coli
Functional_Classification peptidyl prolyl cis trans isomerase
Cellular_Localization Cytoplasm
Gene_Names parA
UniProt_ID P07620
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Peptide 7
Peptide_Sequence GLADRATFVVDPQGIIQA
Peptide_Length 18
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)CN)[C@@H](C)O)C(C)C)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)O)[C@@H](C)CC
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1871.12
Aliphatic_Index 113.88889
Aromaticity 0.05556
Average_Rotatable_Bonds 3.27778
Charge_at_pH_7 -1.00113
Isoelectric_Point 4.10925
Number_of_Hydrogen_Bond_Acceptors 25
Number_of_Hydrogen_Bond_Donors 26
Topological_Polar_Surface_Area 792.14000
X_logP_energy -7.71393
Interaction Information
Affinity IC50=62.1 uM
Affinity_Assay protease-free PPIase assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title The Protein-Free IANUS Peptide Array Uncovers Interaction Sites between Escherichia coli Parvulin 10 and Alkyl Hydroperoxide Reductase
Release_Year 2010
PMID 20806779
DOI 10.1021/bi101015p