PPIRE17969

Target Protein Information
Protein_Name Anti-apoptotic protein NR13
Protein_Sequence MPGSLKEETALLLEDYFQHRAGGAALPPSATAAELRRAAAELERRERPFFRSCAPLARAEPREAAALLRKVAAQLEAEGGLNWGRLLALVVFTGTLAAALAESGCEEGPSRLAAALAAYLAEEQGEWLEEHGGWDGFCRFFGRHGSQPADQNSTLSNAIMAAAGFGIAGLAFLLVVR
Organism_Source Gallus gallus
Functional_Classification Bcl 2 family
Cellular_Localization Mitochondria
Gene_Names NR13
UniProt_ID Q90ZN1
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name M10b1
Peptide_Sequence RRGSPVMEASKAVDVLFLAL
Peptide_Length 20
Peptide_SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)C)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2159.58
Aliphatic_Index 117.00000
Aromaticity 0.05000
Average_Rotatable_Bonds 3.55000
Charge_at_pH_7 0.99990
Isoelectric_Point 9.69016
Number_of_Hydrogen_Bond_Acceptors 29
Number_of_Hydrogen_Bond_Donors 31
Topological_Polar_Surface_Area 872.31000
X_logP_energy -7.11146
Interaction Information
Affinity KD=4.5 mM
Affinity_Assay ELISA
PDB_ID None
Type Antagonist
Structure
Reference Information
Document_Type Research Articles
Title Modulation of Nr-13 antideath activity by peptide aptamers
Release_Year 2007
PMID 16909120
DOI 10.1038/sj.onc.1209832