PPIRE17970

Target Protein Information
Protein_Name Anti-apoptotic protein NR13
Protein_Sequence MPGSLKEETALLLEDYFQHRAGGAALPPSATAAELRRAAAELERRERPFFRSCAPLARAEPREAAALLRKVAAQLEAEGGLNWGRLLALVVFTGTLAAALAESGCEEGPSRLAAALAAYLAEEQGEWLEEHGGWDGFCRFFGRHGSQPADQNSTLSNAIMAAAGFGIAGLAFLLVVR
Organism_Source Gallus gallus
Functional_Classification Bcl 2 family
Cellular_Localization Mitochondria
Gene_Names NR13
UniProt_ID Q90ZN1
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name B16m3
Peptide_Sequence PRGAPLWLCWVWQMLETMLP
Peptide_Length 20
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CS)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2427.97
Aliphatic_Index 97.50000
Aromaticity 0.15000
Average_Rotatable_Bonds 3.50000
Charge_at_pH_7 -0.06222
Isoelectric_Point 6.23243
Number_of_Hydrogen_Bond_Acceptors 28
Number_of_Hydrogen_Bond_Donors 29
Topological_Polar_Surface_Area 794.54000
X_logP_energy -0.07933
Interaction Information
Affinity KD=0.2 mM
Affinity_Assay ELISA
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Modulation of Nr-13 antideath activity by peptide aptamers
Release_Year 2007
PMID 16909120
DOI 10.1038/sj.onc.1209832