PPIRE18005
Target Protein Information
| Protein_Name | Cytochrome c |
|---|---|
| Protein_Sequence | MGDVEKGKKIFVQKCAQCHTVEKGGKHKTGPNLHGLFGRKTGQAPGFTYTDANKNKGITWKEETLMEYLENPKKYIPGTKMIFAGIKKKTEREDLIAYLKKATNE |
| Organism_Source | Equus caballus |
| Functional_Classification | oxidoreductases |
| Cellular_Localization | Mitochondria |
| Gene_Names | CYCS |
| UniProt_ID | P00004 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | C-terminal peptide |
|---|---|
| Peptide_Sequence | EPTEREDLIAYLKEATNK |
| Peptide_Length | 18 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC(=O)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)O)[C@@H](C)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Acetyl |
| C-terminal_Modification | Amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 2120.34 |
|---|---|
| Aliphatic_Index | 76.11111 |
| Aromaticity | 0.05556 |
| Average_Rotatable_Bonds | 4.00000 |
| Charge_at_pH_7 | -1.99591 |
| Isoelectric_Point | 4.29949 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 31 |
| Number_of_Hydrogen_Bond_Donors | 32 |
| Topological_Polar_Surface_Area | 953.45000 |
| X_logP_energy | -8.63533 |
Interaction Information
| Affinity | KD=5 uM |
|---|---|
| Affinity_Assay | circular dichroism |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | A Noncovalent Peptide Complex as a Model for an Early Folding Intermediate of Cytochrome c |
| Release_Year | 1993 |
| PMID | 8399132 |
| DOI | 10.1021/bi00089a022 |