PPIRE18039

Target Protein Information
Protein_Name Ig gamma-1 chain C region secreted form/Immunoglobulin kappa constant
Protein_Sequence AKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSPRPSETVTCNVAHPASSTKVDKKIVPRDCGCKPCICTVPEVSSVFIFPPKPKDVLTITLTPKVTCVVVDISKDDPEVQFSWFVDDVEVHTAQTQPREEQFNSTFRSVSELPIMHQDWLNGKEFKCRVNSAAFPAPIEKTISKTKGRPKAPQVYTIPPPKEQMAKDKVSLTCMITDFFPEDITVEWQWNGQPAENYKNTQPIMNTNGSYFVYSKLNVQKSNWEAGNTFTCSVLHEGLHNHHTEKSLSHSPGK/RADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC
Organism_Source Mus musculus/Mus musculus
Functional_Classification monoclonal antibody
Cellular_Localization Extracellular
Gene_Names Ighg1/Igkc
UniProt_ID P01868/P01837
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name CISHKDMQLG
Peptide_Sequence CISHKDMQLG
Peptide_Length 10
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](N)CS)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1131.33
Aliphatic_Index 78.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 3.90000
Charge_at_pH_7 0.02707
Isoelectric_Point 7.35900
Number_of_Hydrogen_Bond_Acceptors 18
Number_of_Hydrogen_Bond_Donors 17
Topological_Polar_Surface_Area 480.54000
X_logP_energy -5.00470
Interaction Information
Affinity IC50=4.6 uM
Affinity_Assay ELISA
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Epitope mapping of a C5a neutralizing mAb using a combined approach of phage display synthetic peptides and site-directed mutagenesis
Release_Year 1996
PMID None
DOI 10.1016/S1380-2933(96)0042-5