PPIRE18058

Target Protein Information
Protein_Name Guanine nucleotide-binding protein G(i) subunit alpha-1
Protein_Sequence MGCTLSAEDKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEAGYSEEECKQYKAVVYSNTIQSIIAIIRAMGRLKIDFGDAARADDARQLFVLAGAAEEGFMTAELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLDRIAQPNYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKKSPLTICYPEYAGSNTYEEAAAYIQCQFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF
Organism_Source Rattus norvegicus
Functional_Classification GTPases
Cellular_Localization Plasma membrane
Gene_Names Gnai1
UniProt_ID P10824
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name L19_GPR
Peptide_Sequence TMGEEDFFDLLAKSQSKRLDDQRVDLAGYK
Peptide_Length 30
Peptide_SMILES CSCC[C@H](NC(=O)[C@@H](N)[C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 3476.86
Aliphatic_Index 68.33333
Aromaticity 0.10000
Average_Rotatable_Bonds 4.06667
Charge_at_pH_7 -1.99798
Isoelectric_Point 4.40169
Number_of_Hydrogen_Bond_Acceptors 50
Number_of_Hydrogen_Bond_Donors 53
Topological_Polar_Surface_Area 1537.28000
X_logP_energy -15.29966
Interaction Information
Affinity IC50=0.5 uM
Affinity_Assay fluorescence assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title In Vitro Selection of State-Specific Peptide Modulators of G Protein Signaling Using mRNA Display
Release_Year 2004
PMID 15248784
DOI 10.1021/bi0498398