PPIRE18063

Target Protein Information
Protein_Name Guanine nucleotide-binding protein G(i) subunit alpha-1
Protein_Sequence MGCTLSAEDKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEAGYSEEECKQYKAVVYSNTIQSIIAIIRAMGRLKIDFGDAARADDARQLFVLAGAAEEGFMTAELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLDRIAQPNYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKKSPLTICYPEYAGSNTYEEAAAYIQCQFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF
Organism_Source Rattus norvegicus
Functional_Classification GTPases
Cellular_Localization Plasma membrane
Gene_Names Gnai1
UniProt_ID P10824
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name R6A-R
Peptide_Sequence DQRYWWEYL
Peptide_Length 9
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(=O)O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1358.48
Aliphatic_Index 43.33333
Aromaticity 0.44444
Average_Rotatable_Bonds 4.33333
Charge_at_pH_7 -1.00150
Isoelectric_Point 4.18441
Number_of_Hydrogen_Bond_Acceptors 16
Number_of_Hydrogen_Bond_Donors 20
Topological_Polar_Surface_Area 547.75000
X_logP_energy -0.46433
Interaction Information
Affinity KD=15 uM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title In Vitro Selection of State-Specific Peptide Modulators of G Protein Signaling Using mRNA Display
Release_Year 2004
PMID 15248784
DOI 10.1021/bi0498398