PPIRE18130

Target Protein Information
Protein_Name Protein Tat
Protein_Sequence MEPVDPRLEPWKHPGSQPKTACTNCYCKKCCFHCQVCFITKALGISYGRKKRRQRRRAHQNSQTHQASLSKQPTSQPRGDPTGPKE
Organism_Source Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)
Functional_Classification viral regulatory
Cellular_Localization Nucleus
Gene_Names tat
UniProt_ID P04608
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name KP-Z-41
Peptide_Sequence RVRCRQKGGQTICIII
Peptide_Length 16
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CS)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1844.27
Aliphatic_Index 115.62500
Aromaticity 0.00000
Average_Rotatable_Bonds 4.06250
Charge_at_pH_7 3.87373
Isoelectric_Point 11.38120
Number_of_Hydrogen_Bond_Acceptors 26
Number_of_Hydrogen_Bond_Donors 32
Topological_Polar_Surface_Area 817.95000
X_logP_energy -8.53629
Interaction Information
Affinity KD=1 nM
Affinity_Assay electrophoretic mobility shift assay
PDB_ID 2KX5
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Essential structural requirements for specific recognition of HIV TAR RNA by peptide mimetics of Tat protein
Release_Year 2011
PMID 20724442
DOI 10.1093/nar/gkq713