PPIRE18139

Target Protein Information
Protein_Name Cellular tumor antigen p53
Protein_Sequence MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD
Organism_Source Homo sapiens
Functional_Classification tumor suppressor
Cellular_Localization Nucleus
Gene_Names TP53
UniProt_ID P04637
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name TOPBP1-derived peptide
Peptide_Sequence LFSDLNKLKP
Peptide_Length 10
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1174.41
Aliphatic_Index 117.00000
Aromaticity 0.10000
Average_Rotatable_Bonds 3.90000
Charge_at_pH_7 0.99784
Isoelectric_Point 9.53730
Number_of_Hydrogen_Bond_Acceptors 16
Number_of_Hydrogen_Bond_Donors 15
Topological_Polar_Surface_Area 469.09000
X_logP_energy -2.75090
Interaction Information
Affinity KD=11 nM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Identification of Amino Acids Essential for Antibody Binding by mRNA-Display Using a Random Peptide Library: An Anti-Human Tumor Protein p53 Antibody as a Model
Release_Year 2009
PMID 18855146
DOI 10.1007/s12033-008-9113-0