PPIRE18147
Target Protein Information
| Protein_Name | None |
|---|---|
| Protein_Sequence | MENITSGFLGPLLVLQAGFFWLTRILTIPQSLDSWWTSLNFLGGTTVCLGQNSQSPTSNHSPTSCPPTCPGYRWMCLRRFIIFLFILLLCLIFLLVLLDYQGMLPVCPLIPGSSTTSTGPCRTCTTPAQGTSMYPSCCCTKPSDGNCTCIPIPSSWAFGKFLWEWASARFSWLSLLVPFVQWFVGLSPTVWLSVIWMMWYWGPSLYSILSPFLPLLPIFFCLWVYI |
| Organism_Source | Hepatitis B virus |
| Functional_Classification | viral envelope proteins |
| Cellular_Localization | Extracellular |
| Gene_Names | S gene subtype ayw2 |
| UniProt_ID | Q69601 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | P2 |
|---|---|
| Peptide_Sequence | HTLHRQVPKHWL |
| Peptide_Length | 12 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)C(C)C)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1551.82 |
|---|---|
| Aliphatic_Index | 89.16667 |
| Aromaticity | 0.08333 |
| Average_Rotatable_Bonds | 3.91667 |
| Charge_at_pH_7 | 2.27041 |
| Isoelectric_Point | 11.65182 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 20 |
| Number_of_Hydrogen_Bond_Donors | 22 |
| Topological_Polar_Surface_Area | 627.70000 |
| X_logP_energy | -3.35453 |
Interaction Information
| Affinity | KD=697.84 uM |
|---|---|
| Affinity_Assay | Isothermal Titration Calorimetry |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Blocking peptides against HBV: PreS1 protein selected from a phage display library |
| Release_Year | 2011 |
| PMID | 21856287 |
| DOI | 10.1016/j.bbrc.2011.08.014 |