PPIRE18286

Target Protein Information
Protein_Name Interleukin-17A
Protein_Sequence MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA
Organism_Source Homo sapiens
Functional_Classification interleukins
Cellular_Localization Extracellular
Gene_Names IL17A
UniProt_ID Q16552
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name PyroEGGIHVTIPADLWDWINK
Peptide_Sequence PyrEGGIHVTIPADLWDWINK
Peptide_Length 21
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)CNC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification pyroglutamate
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2480.81
Aliphatic_Index 92.85714
Aromaticity 0.14286
Average_Rotatable_Bonds 3.57143
Charge_at_pH_7 -0.90959
Isoelectric_Point 5.51930
Number_of_Hydrogen_Bond_Acceptors 31
Number_of_Hydrogen_Bond_Donors 34
Topological_Polar_Surface_Area 966.17000
X_logP_energy -5.02693
Interaction Information
Affinity KD=60 nM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Pyroglutamate and O-Linked Glycan Determine Functional Production of Anti-IL17A and Anti-IL22 Peptide-Antibody Bispecific Genetic Fusions
Release_Year 2013
PMID 23184956
DOI 10.1074/jbc.M112.417717