PPIRE18422

Target Protein Information
Protein_Name Delta-type opioid receptor
Protein_Sequence MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
Organism_Source Homo sapiens
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names OPRD1
UniProt_ID P41143
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name [(2S-3R)-TMT1]DPDPE
Peptide_Sequence XXGFX
Peptide_Length 5
Peptide_SMILES NCC(=O)NCC(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O
Chemical_Modification X1=(2S-3R)-2'-6'-dimethyltyrosine; X2=3-3-dimethylcysteine; X5=3-3-dimethylcysteine
Cyclization_Method Side chain-side chain cyclization; X2<-->X5; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 393.40
Aliphatic_Index 0.00000
Aromaticity 0.20000
Average_Rotatable_Bonds 2.20000
Charge_at_pH_7 -0.00202
Isoelectric_Point 6.10000
Number_of_Hydrogen_Bond_Acceptors 6
Number_of_Hydrogen_Bond_Donors 6
Topological_Polar_Surface_Area 179.72000
X_logP_energy -2.89420
Interaction Information
Affinity IC50=5 nM
Affinity_Assay Radioligand binding assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Design in Topographical Space of Peptide and Peptidomimetic Ligands That Affect Behavior. A Chemist-鍌欒兌閸嬨劑宕曢弻銉﹀仒 Glimpse at the Mind-Body Problem
Release_Year 2001
PMID 11352717
DOI 10.1021/ar990063q