PPIRE18585

Target Protein Information
Protein_Name T-cell surface glycoprotein CD4
Protein_Sequence MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI
Organism_Source Homo sapiens
Functional_Classification cell surface receptors
Cellular_Localization Plasma membrane
Gene_Names CD4
UniProt_ID P01730
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Feglymycin
Peptide_Sequence XPXYXXXAVXPID
Peptide_Length 13
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)CNC(=O)CNC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)CN)C(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)O
Chemical_Modification X1=3-5-dihydroxyphenylglycine; X3=4-hydroxyphenylglycine; X5=3-5-dihydroxyphenylglycine; X6=4-hydroxyphenylglycine; X7=3-5-dihydroxyphenylglycine; X10=3-5-dihydroxyphenylglycine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1116.20
Aliphatic_Index 60.00000
Aromaticity 0.07692
Average_Rotatable_Bonds 2.30769
Charge_at_pH_7 -1.00242
Isoelectric_Point 3.74999
Number_of_Hydrogen_Bond_Acceptors 16
Number_of_Hydrogen_Bond_Donors 14
Topological_Polar_Surface_Area 452.47000
X_logP_energy -5.83830
Interaction Information
Affinity EC50=4.4 uM
Affinity_Assay ELISA
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Feglymycin a unique natural bacterial antibiotic peptide inhibits HIV entry by targeting the viral envelope protein gp120
Release_Year 2012
PMID 22959895
DOI 10.1016/j.virol.2012.08.007