PPIRE18588

Target Protein Information
Protein_Name Outer capsid glycoprotein VP7
Protein_Sequence MASLLLLVLAAAVTAQLNIVPSTHPEVCVLYADDHQADANKFNGNFTQIFHSYNSITLSFMSYSSSSYDVIDIISKYDLSSCNILAIDVFNASMDFNVFLQSTNNCSKYNANKVHHVKLPRGEEWFSYSKNLKFCPLSDSLIGMYCDTQLSDTYFEISTGGTYEVTDIPEFTQMGYTFHSSEEFYLCHRISSEAWLNYHLFYRDYDVSGVISKQVNWGNVWSGFKTFAQVLYKILDLFFNSKRNVEPRA
Organism_Source Rotavirus B (isolate RVB/Human/China/ADRV/1982)
Functional_Classification capsid glycoprotein
Cellular_Localization Extracellular
Gene_Names None
UniProt_ID P18570
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name VP761
Peptide_Sequence SNPEARNTIFVSTQYVKLQVMADDGRWAHGDTTDFRMVIVNRPGQLGFVTSGKVTASKEL
Peptide_Length 60
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CO)[C@@H](C)O)[C@@H](C)CC)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(C)C)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 6641.50
Aliphatic_Index 73.00000
Aromaticity 0.08333
Average_Rotatable_Bonds 3.65000
Charge_at_pH_7 1.09248
Isoelectric_Point 9.21994
Number_of_Hydrogen_Bond_Acceptors 94
Number_of_Hydrogen_Bond_Donors 99
Topological_Polar_Surface_Area 2837.64000
X_logP_energy -32.30942
Interaction Information
Affinity KD=95 nM
Affinity_Assay plasmon waveguide resonance
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title A peptide derived from the rotavirus outer capsid protein VP7 permeabilizes artificial membranes
Release_Year 2014
PMID 24746450
DOI 10.1016/j.bbamem.2014.04.005