PPIRE18649
Target Protein Information
| Protein_Name | Rhodopsin |
|---|---|
| Protein_Sequence | MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRNCMVTTLCCGKNPLGDDEASTTVSKTETSQVAPA |
| Organism_Source | Bos taurus |
| Functional_Classification | G protein-coupled receptor |
| Cellular_Localization | Plasma membrane |
| Gene_Names | RHO |
| UniProt_ID | P02699 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | peptide 6 |
|---|---|
| Peptide_Sequence | IKENLKDCGLX |
| Peptide_Length | 11 |
| Peptide_SMILES | CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)O |
| Chemical_Modification | X11=R-cyclohexylalanine |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1189.39 |
|---|---|
| Aliphatic_Index | 106.36364 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 3.90909 |
| Charge_at_pH_7 | -0.06236 |
| Isoelectric_Point | 6.31682 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 18 |
| Number_of_Hydrogen_Bond_Donors | 18 |
| Topological_Polar_Surface_Area | 524.05000 |
| X_logP_energy | -4.94990 |
Interaction Information
| Affinity | IC50=200 uM |
|---|---|
| Affinity_Assay | Bio-Layer Interferometry |
| PDB_ID | 1AQG |
| Type | Agonist |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Relative Strength of Cation-(Pi) vs Salt-Bridge Interactions: The GtR(340-350) Peptide/Rhodopsin System |
| Release_Year | 2006 |
| PMID | 16756308 |
| DOI | 10.1021/ja058513z |