PPIRE18695

Target Protein Information
Protein_Name Alpha-hemolysin
Protein_Sequence MKTRIVSSVTTTLLLGSILMNPVAGAADSDINIKTGTTDIGSNTTVKTGDLVTYDKENGMHKKVFYSFIDDKNHNKKLLVIRTKGTIAGQYRVYSEEGANKSGLAWPSAFKVQLQLPDNEVAQISDYYPRNSIDTKEYMSTLTYGFNGNVTGDDTGKIGGLIGANVSIGHTLKYVQPDFKTILESPTDKKVGWKVIFNNMVNQNWGPYDRDSWNPVYGNQLFMKTRNGSMKAADNFLDPNKASSLLSSGFSPDFATVITMDRKASKQQTNIDVIYERVRDDYQLHWTSTNWKGTNTKDKWTDRSSERYKIDWEKEEMTN
Organism_Source Staphylococcus aureus
Functional_Classification pore forming toxins
Cellular_Localization Plasma membrane
Gene_Names hly
UniProt_ID P09616
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name CAMA
Peptide_Sequence KWKLFKKIGIGKFLHSAKKF
Peptide_Length 20
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)[C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2405.02
Aliphatic_Index 83.00000
Aromaticity 0.20000
Average_Rotatable_Bonds 4.30000
Charge_at_pH_7 7.08683
Isoelectric_Point 11.57869
Number_of_Hydrogen_Bond_Acceptors 30
Number_of_Hydrogen_Bond_Donors 31
Topological_Polar_Surface_Area 863.06000
X_logP_energy -1.61020
Interaction Information
Affinity KD=6.3 uM
Affinity_Assay fluorescence spectroscopy
PDB_ID None
Type Ion channel modulator
Structure
Reference Information
Document_Type Research Articles
Title Protein Nanopore-Based Single-Molecule Exploration of Copper Binding to an Antimicrobial-Derived Histidine-Containing Chimera Peptide
Release_Year 2012
PMID 23140333
DOI 10.1021/la303782d