PPIRE18824

Target Protein Information
Protein_Name Chaperone NapD
Protein_Sequence MHTNWQVCSLVVQAKSERISDISTQLNAFPGCEVAVSDAPSGQLIVVVEAEDSETLIQTIESVRNVEGVLAVSLVYHQQEEQGEETP
Organism_Source Escherichia coli O157:H7
Functional_Classification chaperones
Cellular_Localization Cytoplasm
Gene_Names napD
UniProt_ID P0A9I6
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name NapA signal peptide A17Q variant
Peptide_Sequence MNNNSRRFMKASAGFQAVGASALAAASAST
Peptide_Length 30
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)O)[C@@H](C)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2988.35
Aliphatic_Index 52.66667
Aromaticity 0.06667
Average_Rotatable_Bonds 3.30000
Charge_at_pH_7 2.99768
Isoelectric_Point 12.51648
Number_of_Hydrogen_Bond_Acceptors 46
Number_of_Hydrogen_Bond_Donors 48
Topological_Polar_Surface_Area 1350.78000
X_logP_energy -21.51736
Interaction Information
Affinity KD=1100 nM
Affinity_Assay Isothermal Titration Calorimetry
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Overlapping transport and chaperone-binding functions within a bacterial twin-arginine signal peptide
Release_Year 2012
PMID 22329966
DOI 10.1111/j.1365-2958.2012.08005.x