PPIRE18846

Target Protein Information
Protein_Name Adapter molecule crk
Protein_Sequence MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVARSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIYARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECNGKRGHFPFTHVRLLDQQNPDEDFS
Organism_Source Mus musculus
Functional_Classification SH3 domain containing proteins
Cellular_Localization Cytoplasm
Gene_Names Crk
UniProt_ID Q64010
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Sos
Peptide_Sequence PPPVPPRRRR
Peptide_Length 10
Peptide_SMILES CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1227.48
Aliphatic_Index 29.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 3.20000
Charge_at_pH_7 3.99797
Isoelectric_Point 12.97715
Number_of_Hydrogen_Bond_Acceptors 15
Number_of_Hydrogen_Bond_Donors 19
Topological_Polar_Surface_Area 523.67000
X_logP_energy -5.07992
Interaction Information
Affinity KD=1.5 uM
Affinity_Assay Isothermal Titration Calorimetry
PDB_ID 1CKB
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Role of Electrostatic Interactions in Binding of Peptides and Intrinsically Disordered Proteins to Their Folded Targets. 1. NMR and MD Characterization of the Complex between the c-Crk N-SH3 Domain and the Peptide Sos
Release_Year 2014
PMID 25207671
DOI 10.1021/bi500904f