PPIRE18933

Target Protein Information
Protein_Name Cellular tumor antigen p53
Protein_Sequence MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD
Organism_Source Homo sapiens
Functional_Classification Sequence specific DNA binding transcription factors
Cellular_Localization Nucleus
Gene_Names TP53
UniProt_ID P04637
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name DP2
Peptide_Sequence EDEEGNDSDEHEE
Peptide_Length 13
Peptide_SMILES NC(=O)C[C@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1533.35
Aliphatic_Index 0.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 4.15385
Charge_at_pH_7 -8.89912
Isoelectric_Point 3.37088
Number_of_Hydrogen_Bond_Acceptors 26
Number_of_Hydrogen_Bond_Donors 26
Topological_Polar_Surface_Area 840.22000
X_logP_energy -11.70630
Interaction Information
Affinity KD=23 uM
Affinity_Assay fluorescence anisotropy
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Rational design using sequence information only produces a peptide that binds to the intrinsically disordered region of p53
Release_Year 2019
PMID 31253862
DOI 10.1038/s41598-019-44688-0