PPIRE18991

Target Protein Information
Protein_Name Chaperone NapD
Protein_Sequence MHTNWQVCSLVVQAKSERISDISTQLNAFPGCEVAVSDAPSGQLIVVVEAEDSETLIQTIESVRNVEGVLAVSLVYHQQEEQGEETP
Organism_Source Escherichia coli O157:H7
Functional_Classification Chaperones
Cellular_Localization Cytoplasm
Gene_Names napD
UniProt_ID P0A9I6
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name NapA signal peptide
Peptide_Sequence MKDVTSLRRFLALAVALAGSVAGLAIGA
Peptide_Length 28
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2772.35
Aliphatic_Index 139.64286
Aromaticity 0.03571
Average_Rotatable_Bonds 3.28571
Charge_at_pH_7 1.99813
Isoelectric_Point 11.47970
Number_of_Hydrogen_Bond_Acceptors 37
Number_of_Hydrogen_Bond_Donors 40
Topological_Polar_Surface_Area 1096.83000
X_logP_energy -9.74256
Interaction Information
Affinity KD=7 nM
Affinity_Assay Isothermal Titration Calorimetry
PDB_ID 2JSX
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Structural diversity in twin-arginine signal peptide-binding proteins
Release_Year 2007
PMID 17901208
DOI 10.1073/pnas.0703967104