PPIRE19084
Target Protein Information
| Protein_Name | Uncharacterized PPE family protein PPE61 |
|---|---|
| Protein_Sequence | MFMDFAMLPPEVNSTRMYSGPGAGSLWAAAAAWDQVSAELQSAAETYRSVIASLTGWQWLGPSSVRMGAAVTPYVEWLTTTAAQARQTATQITAAATGFEQAFAMTVPPPAIMANRAQVLSLIATNFFGQNTAAIAALETQYAEMWEQDATAMYDYAATSAAARTLTPFTSPQQDTNSAGLPAQSAEVSRATANAGAADGNWLGNLLEEIGILLLPIAPELTPFFLEAGEIVNAIPFPSIVGDEFCLLDGLLAWYATIGSINNINSMGTGIIGAEKNLGILPELGSAAAAAAPPPADIAPAFLAPLTSMAKSLSDGALRGPGEVSAAMRGAGTIGQMSVPPAWKAPAVTTVRAFDATPMTTLPGGDAPAAGVPGLPGMPASGAGRAGVVPRYGVRLTVMTRPLSGG |
| Organism_Source | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
| Functional_Classification | cell wall proteins |
| Cellular_Localization | Extracellular |
| Gene_Names | PPE61 |
| UniProt_ID | P9WHX9 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | TB124 |
|---|---|
| Peptide_Sequence | LEEIGILLL |
| Peptide_Length | 9 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CC(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1012.25 |
|---|---|
| Aliphatic_Index | 260.00000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 3.88889 |
| Charge_at_pH_7 | -1.99847 |
| Isoelectric_Point | 3.61369 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 12 |
| Number_of_Hydrogen_Bond_Donors | 12 |
| Topological_Polar_Surface_Area | 370.72000 |
| X_logP_energy | 0.91430 |
Interaction Information
| Affinity | KD=11 nM |
|---|---|
| Affinity_Assay | luminescent oxygen channeling immunoassay |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Identification of MHC class II restricted T-cell-mediated reactivity against MHC class I binding Mycobacterium tuberculosis peptides |
| Release_Year | 2011 |
| PMID | 21294723 |
| DOI | 10.1111/j.1365-2567.2010.03383.x |