PPIRE19176

Target Protein Information
Protein_Name Protein S100-A4
Protein_Sequence MACPLEKALDVMVSTFHKYSGKEGDKFKLNKSELKELLTRELPSFLGKRTDEAAFQKLMSNLDSNRDNEVDFQEYCVFLSCIAMMCNEFFEGFPDKQPRKK
Organism_Source Homo sapiens
Functional_Classification calcium binding proteins
Cellular_Localization Cytoplasm
Gene_Names S100A4
UniProt_ID P26447
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name FITC-MIIA1908-1923
Peptide_Sequence DAMNREVSSLKNKLRR
Peptide_Length 16
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification FITC-Ahx
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1917.22
Aliphatic_Index 73.12500
Aromaticity 0.00000
Average_Rotatable_Bonds 4.37500
Charge_at_pH_7 2.99961
Isoelectric_Point 11.55035
Number_of_Hydrogen_Bond_Acceptors 29
Number_of_Hydrogen_Bond_Donors 34
Topological_Polar_Surface_Area 938.80000
X_logP_energy -11.68579
Interaction Information
Affinity KD=1.7 uM
Affinity_Assay Fluorescence Polarization
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structure of Ca2+-Bound S100A4 and Its Interaction with Peptides Derived from Nonmuscle Myosin-IIA
Release_Year 2008
PMID 18410126
DOI 10.1021/bi702537s