PPIRE19178

Target Protein Information
Protein_Name Centrin-2
Protein_Sequence MASNFKKANMASSSQRKRMSPKPELTEEQKQEIREAFDLFDADGTGTIDVKELKVAMRALGFEPKKEEIKKMISEIDKEGTGKMNFGDFLTVMTQKMSEKDTKEEILKAFKLFDDDETGKISFKNLKRVAKELGENLTDEELQEMIDEADRDGDGEVSEQEFLRIMKKTSLY
Organism_Source Homo sapiens
Functional_Classification EF hand calcium binding proteins
Cellular_Localization Nucleus
Gene_Names CETN2
UniProt_ID P41208
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name P1-XPC
Peptide_Sequence NWKLLAKGLLIRERLKR
Peptide_Length 17
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2107.62
Aliphatic_Index 143.52941
Aromaticity 0.05882
Average_Rotatable_Bonds 4.47059
Charge_at_pH_7 4.99886
Isoelectric_Point 12.26273
Number_of_Hydrogen_Bond_Acceptors 26
Number_of_Hydrogen_Bond_Donors 33
Topological_Polar_Surface_Area 888.86000
X_logP_energy -4.27599
Interaction Information
Affinity KD=100 uM
Affinity_Assay flow dialysis
PDB_ID 2A4J
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Slow Backbone Dynamics of the C-Terminal Fragment of Human Centrin 2 in Complex with a Target Peptide Probed by Cross-Correlated Relaxation in Multiple-Quantum NMR Spectroscopy
Release_Year 2006
PMID 17154538
DOI 10.1021/bi061469v