PPIRE19183
Target Protein Information
| Protein_Name | Protein Tat |
|---|---|
| Protein_Sequence | MPGPWVAMIMLPQPKESFGGKPIGWLFWNTCKGPRRDCPHCCCPICSWHCQLCFLQKNLGINYGSGPRRRGTRGKGRRIRRTASGGDQRREADSQRSFTNMDQ |
| Organism_Source | Bovine immunodeficiency virus (strain R29) |
| Functional_Classification | Viral transcriptional activators |
| Cellular_Localization | Nucleus |
| Gene_Names | tat |
| UniProt_ID | P19564 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | BIV Tat(65-81) |
|---|---|
| Peptide_Sequence | SGPRPRGTRGKGRRIRR |
| Peptide_Length | 17 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H](N)CO)[C@@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Acetyl |
| C-terminal_Modification | Amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1963.29 |
|---|---|
| Aliphatic_Index | 22.94118 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 3.94118 |
| Charge_at_pH_7 | 7.99767 |
| Isoelectric_Point | 13.27984 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 28 |
| Number_of_Hydrogen_Bond_Donors | 40 |
| Topological_Polar_Surface_Area | 1011.12000 |
| X_logP_energy | -14.91581 |
Interaction Information
| Affinity | KD=6 nM |
|---|---|
| Affinity_Assay | gel shift assay |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Structure-based design of a dimeric RNA-peptide complex |
| Release_Year | 2001 |
| PMID | 11226168 |
| DOI | 10.1093/emboj/20.1.178 |