PPIRE19188
Target Protein Information
| Protein_Name | Protein Tat |
|---|---|
| Protein_Sequence | MPGPWVAMIMLPQPKESFGGKPIGWLFWNTCKGPRRDCPHCCCPICSWHCQLCFLQKNLGINYGSGPRRRGTRGKGRRIRRTASGGDQRREADSQRSFTNMDQ |
| Organism_Source | Bovine immunodeficiency virus (strain R29) |
| Functional_Classification | Viral transcriptional activators |
| Cellular_Localization | Nucleus |
| Gene_Names | tat |
| UniProt_ID | P19564 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | BIVdimer(G6) |
|---|---|
| Peptide_Sequence | GRGTRGKGRRIGGGGGGRGTRGKGRRIG |
| Peptide_Length | 28 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CNC(=O)CNC(=O)CNC(=O)CNC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)CN)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)O)C(=O)NCC(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Acetyl |
| C-terminal_Modification | Amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 2751.12 |
|---|---|
| Aliphatic_Index | 27.85714 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 3.60714 |
| Charge_at_pH_7 | 9.99737 |
| Isoelectric_Point | 13.34792 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 41 |
| Number_of_Hydrogen_Bond_Donors | 57 |
| Topological_Polar_Surface_Area | 1436.72000 |
| X_logP_energy | -24.45454 |
Interaction Information
| Affinity | KD=5 nM |
|---|---|
| Affinity_Assay | gel shift assay |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Structure-based design of a dimeric RNA-peptide complex |
| Release_Year | 2001 |
| PMID | 11226168 |
| DOI | 10.1093/emboj/20.1.178 |