PPIRE19274

Target Protein Information
Protein_Name Transcriptional coactivator YAP1
Protein_Sequence MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRKLPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQELLRQAMRNINPSTANSPKCQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVLAATKLDKESFLTWL
Organism_Source Homo sapiens
Functional_Classification Transcriptional co activators
Cellular_Localization Nucleus
Gene_Names YAP1
UniProt_ID P46937
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name KbAbAEYPPYPPPPYPSG
Peptide_Sequence KGAGAEYPPYPPPPYPSG
Peptide_Length 18
Peptide_SMILES C[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)NCC(=O)O
Chemical_Modification b2=D-Ala; b4=D-Ala
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1730.94
Aliphatic_Index 12.50000
Aromaticity 0.18750
Average_Rotatable_Bonds 2.37500
Charge_at_pH_7 -0.00309
Isoelectric_Point 6.38902
Number_of_Hydrogen_Bond_Acceptors 23
Number_of_Hydrogen_Bond_Donors 16
Topological_Polar_Surface_Area 582.53000
X_logP_energy -3.28410
Interaction Information
Affinity KD=6 uM
Affinity_Assay fluorescence spectroscopy
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Solution Structures of the YAP65 WW Domain and the Variant L30K in Complex with the Peptides GTPPPPYTVG N-(n-octyl)-GPPPY and PLPPY and the Application of Peptide Libraries Reveal a Minimal Binding Epitope
Release_Year 2001
PMID None
DOI 10.1006/jmbi.2001.5199