PPIRE19275

Target Protein Information
Protein_Name Olfactory marker protein
Protein_Sequence MAEDGPQKQQLDMPLVLDQDLTKQMRLRVESLKQRGEKKQDGEKLLRPAESVYRLDFIQQQKLQFDHWNVVLDKPGKVTITGTSQNWTPDLTNLMTRQLLDPAAIFWRKEDSDAMDWNEADALEFGERLSDLAKIRKVMYFLITFGEGVEPANLKASVVFNQL
Organism_Source Rattus norvegicus
Functional_Classification signal transduction modulators
Cellular_Localization Cytoplasm
Gene_Names Omp
UniProt_ID P08523
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Bex1 peptide 50-75
Peptide_Sequence RGGRRRFRVRQPIAHYRWDLMQRVGE
Peptide_Length 26
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 3296.82
Aliphatic_Index 56.15385
Aromaticity 0.11538
Average_Rotatable_Bonds 4.23077
Charge_at_pH_7 6.09024
Isoelectric_Point 12.50089
Number_of_Hydrogen_Bond_Acceptors 42
Number_of_Hydrogen_Bond_Donors 57
Topological_Polar_Surface_Area 1502.71000
X_logP_energy -14.04664
Interaction Information
Affinity KD=150 mM
Affinity_Assay NMR chemical shift perturbation
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Olfactory Marker Protein (OMP) Exhibits a b-Clam Fold in Solution: Implications for Target Peptide Interaction and Olfactory Signal Transduction
Release_Year 2002
PMID None
DOI 10.1016/S00222836(02)00282-6