PPIRE19340

Target Protein Information
Protein_Name Somatostatin receptor type 4
Protein_Sequence MSAPSTLPPGGEEGLGTAWPSAANASSAPAEAEEAVAGPGDARAAGMVAIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASSAALRHWPFGSVLCRAVLSVDGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAIFADTRPARGGQAVACNLQWPHPAWSAVFVVYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVVVFVLCWMPFYVVQLLNLFVTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRFFQRVLCLRCCLLEGAGGAEEEPLDYYATALKSKGGAGCMCPPLPCQQEALQPEPGRKRIPLTRTTTF
Organism_Source Homo sapiens
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names SSTR4
UniProt_ID P31391
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Octreotide
Peptide_Sequence fCFwKTCT
Peptide_Length 8
Peptide_SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CS)NC(=O)[C@@H](N)Cc1ccccc1)[C@@H](C)O)C(=O)O
Chemical_Modification f1=D-phenylalanine; w4=D-tryptophan; T8=Thr-ol
Cyclization_Method Side chain-side chain cyclization; C2<-->C7; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Thr-ol
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1035.24
Aliphatic_Index 0.00000
Aromaticity 0.37500
Average_Rotatable_Bonds 3.62500
Charge_at_pH_7 0.87374
Isoelectric_Point 8.22969
Number_of_Hydrogen_Bond_Acceptors 14
Number_of_Hydrogen_Bond_Donors 15
Topological_Polar_Surface_Area 349.29000
X_logP_energy -1.24850
Interaction Information
Affinity Ki=0.25 nM
Affinity_Assay Radioligand binding assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Peptide aromatic interactions modulated by fluorinated residues: Synthesis structure and biological activity of Somatostatin analogs containing 3-(3--5--difluorophenyl)-alanine
Release_Year 2016
PMID 27271737
DOI 10.1038/srep27285