PPIRE19350

Target Protein Information
Protein_Name Somatostatin receptor type 4
Protein_Sequence MSAPSTLPPGGEEGLGTAWPSAANASSAPAEAEEAVAGPGDARAAGMVAIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASSAALRHWPFGSVLCRAVLSVDGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAIFADTRPARGGQAVACNLQWPHPAWSAVFVVYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVVVFVLCWMPFYVVQLLNLFVTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRFFQRVLCLRCCLLEGAGGAEEEPLDYYATALKSKGGAGCMCPPLPCQQEALQPEPGRKRIPLTRTTTF
Organism_Source Homo sapiens
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names SSTR4
UniProt_ID P31391
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name [L-Dfp7-D-Trp8]-SRIF
Peptide_Sequence AGCKNFXwKTFTSC
Peptide_Length 14
Peptide_SMILES C[C@H](N)C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)O)[C@@H](C)O)[C@@H](C)O
Chemical_Modification X7=L-3-(3--5--difluorophenyl)alanine; w8=D-tryptophan
Cyclization_Method Side chain-side chain cyclization; C3<-->C14; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1549.78
Aliphatic_Index 7.14286
Aromaticity 0.21429
Average_Rotatable_Bonds 3.42857
Charge_at_pH_7 1.87344
Isoelectric_Point 8.82168
Number_of_Hydrogen_Bond_Acceptors 23
Number_of_Hydrogen_Bond_Donors 24
Topological_Polar_Surface_Area 613.23000
X_logP_energy -7.06030
Interaction Information
Affinity Ki=16 nM
Affinity_Assay Radioligand binding assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Peptide aromatic interactions modulated by fluorinated residues: Synthesis structure and biological activity of Somatostatin analogs containing 3-(3--5--difluorophenyl)-alanine
Release_Year 2016
PMID 27271737
DOI 10.1038/srep27285