PPIRE19421

Target Protein Information
Protein_Name Ig gamma-1 chain C region secreted form
Protein_Sequence AKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSPRPSETVTCNVAHPASSTKVDKKIVPRDCGCKPCICTVPEVSSVFIFPPKPKDVLTITLTPKVTCVVVDISKDDPEVQFSWFVDDVEVHTAQTQPREEQFNSTFRSVSELPIMHQDWLNGKEFKCRVNSAAFPAPIEKTISKTKGRPKAPQVYTIPPPKEQMAKDKVSLTCMITDFFPEDITVEWQWNGQPAENYKNTQPIMNTNGSYFVYSKLNVQKSNWEAGNTFTCSVLHEGLHNHHTEKSLSHSPGK
Organism_Source Mus musculus
Functional_Classification immunoglobulins
Cellular_Localization Extracellular
Gene_Names Ighg1
UniProt_ID P01868
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name peptide 2
Peptide_Sequence DYKDDDDL
Peptide_Length 8
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 997.97
Aliphatic_Index 48.75000
Aromaticity 0.12500
Average_Rotatable_Bonds 4.12500
Charge_at_pH_7 -4.00093
Isoelectric_Point 3.54502
Number_of_Hydrogen_Bond_Acceptors 16
Number_of_Hydrogen_Bond_Donors 16
Topological_Polar_Surface_Area 499.77000
X_logP_energy -4.71120
Interaction Information
Affinity KD=2 mM
Affinity_Assay NMR chemical shift perturbation
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Chemical shift differences between free and Fab-bound peptide correlate with a two-stage selection of peptide sequences from a random phage display library to delineate critical and non-critical residues for antibody recognition
Release_Year 1995
PMID 7775004
DOI 10.1111/j.1399-3011.1995.tb01562.x