PPIRE19430
Target Protein Information
| Protein_Name | Rhodopsin |
|---|---|
| Protein_Sequence | MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRNCMVTTLCCGKNPLGDDEASTTVSKTETSQVAPA |
| Organism_Source | Bos taurus |
| Functional_Classification | G protein-coupled receptor |
| Cellular_Localization | Plasma membrane |
| Gene_Names | RHO |
| UniProt_ID | P02699 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Gt-340-350_K341R |
|---|---|
| Peptide_Sequence | IRENLKDCGLF |
| Peptide_Length | 11 |
| Peptide_SMILES | CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1307.53 |
|---|---|
| Aliphatic_Index | 106.36364 |
| Aromaticity | 0.09091 |
| Average_Rotatable_Bonds | 4.09091 |
| Charge_at_pH_7 | -0.06207 |
| Isoelectric_Point | 6.31741 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 18 |
| Number_of_Hydrogen_Bond_Donors | 20 |
| Topological_Polar_Surface_Area | 559.93000 |
| X_logP_energy | -4.20433 |
Interaction Information
| Affinity | IC50=200 nM |
|---|---|
| Affinity_Assay | ELISA |
| PDB_ID | None |
| Type | Allosteric modulator |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Potent Peptide Analogues of a G Protein Receptor-binding Region Obtained with a Combinatorial Library |
| Release_Year | 1996 |
| PMID | 8550587 |
| DOI | 10.1074/jbc.271.1.361 |