PPIPT00031

Target Protein Information
Protein_Name Histone-binding protein RBBP4
Protein_Sequence MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS
Organism_Source Homo sapiens
Functional_Classification Histone-binding protein / chromatin remodeling factor
Cellular_Localization Nucleus
Gene_Names RBBP4
UniProt_ID Q09028
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name FFW (peptide 46)
Peptide_Sequence RRKFAKFQWI
Peptide_Length 10
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Cyclic
N-terminal_Modification Acetyl
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1379.67
Aliphatic_Index 49.00000
Aromaticity 0.30000
Average_Rotatable_Bonds 4.60000
Charge_at_pH_7 3.99739
Isoelectric_point 12.53175
Number_of_Hydrogen_Bond_Acceptors 16
Number_of_Hydrogen_Bond_Donors 21
Topological_Polar_Surface_Area 559.94000
X_logP_energy -1.91306
Interaction Information
Affinity IC50=0.023 uM
Affinity_Assay Fluorescence Polarization
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Patent
Title THERAPEUTIC SALL4 PEPTIDE
Release_Year 2019
Patent_ID US20190218253A1