PPIPT00045
Target Protein Information
| Protein_Name | Advanced glycosylation end product-specific receptor |
|---|---|
| Protein_Sequence | MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEPGEEGPTAGSVGGSGLGTLALALGILGGLGTAALLIGVILWQRRQRRGEERKAPENQEEEEERAELNQSEEPEAGESSTGGP |
| Organism_Source | Homo sapiens |
| Functional_Classification | Pattern-recognition receptor (Ig-superfamily) |
| Cellular_Localization | Extracellular |
| Gene_Names | AGER |
| UniProt_ID | Q15109 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | NtermR13 |
|---|---|
| Peptide_Sequence | CKGAPKKPPORLE |
| Peptide_Length | 13 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CS)C(=O)N[C@@H](CCC(=O)O)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1380.67 |
|---|---|
| Aliphatic_Index | 37.69231 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 3.38462 |
| Charge_at_pH_7 | 2.93690 |
| Isoelectric_point | 10.50673 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 20 |
| Number_of_Hydrogen_Bond_Donors | 19 |
| Topological_Polar_Surface_Area | 563.41000 |
| X_logP_energy | -5.49183 |
Interaction Information
| Affinity | KD=66 nM |
|---|---|
| Affinity_Assay | AlphaScreen |
| PDB_ID | None |
| Type | Antagonist |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | AGER-PEPTIDES AND USE THEREOF |
| Release_Year | 2010 |
| Patent_ID | US20100226915A1 |