PPIPT00106
Target Protein Information
| Protein_Name | Neutrophil gelatinase-associated lipocalin |
|---|---|
| Protein_Sequence | MALSVMCLGLALLGVLQSQAQDSTQNLIPAPSLLTVPLQPDFRSDQFRGRWYVVGLAGNAVQKKTEGSFTMYSTIYELQENNSYNVTSILVRDQDQGCRYWIRTFVPSSRAGQFTLGNMHRYPQVQSYNVQVATTDYNQFAMVFFRKTSENKQYFKITLYGRTKELSPELKERFTRFAKSLGLKDDNIIFSVPTDQCIDN |
| Organism_Source | Mus musculus |
| Functional_Classification | Lipocalin family |
| Cellular_Localization | Extracellular |
| Gene_Names | Lcn2 |
| UniProt_ID | P11672 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Peptide12 |
|---|---|
| Peptide_Sequence | CSVLPPFMC |
| Peptide_Length | 9 |
| Peptide_SMILES | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](N)CS)C(C)C)C(=O)N[C@@H](CS)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | Side chain-side chain cyclization; C1<->C9; disulfide bond |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
|
|
|
Peptide Physicochemical
| Molecular_Weight | 996.27 |
|---|---|
| Aliphatic_Index | 75.55556 |
| Aromaticity | 0.11111 |
| Average_Rotatable_Bonds | 2.88889 |
| Charge_at_pH_7 | -0.12597 |
| Isoelectric_point | 5.82601 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 14 |
| Number_of_Hydrogen_Bond_Donors | 11 |
| Topological_Polar_Surface_Area | 298.77000 |
| X_logP_energy | -1.16110 |
Interaction Information
| Affinity | KD=3.4 uM |
|---|---|
| Affinity_Assay | Surface Plasmon Resonance |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | CTLA4-BINDING PROTEIN PEPTIDE-LINKER MASKS |
| Release_Year | 2019 |
| Patent_ID | US20190169245A1 |