PPIPT00109

Target Protein Information
Protein_Name Streptavidin
Protein_Sequence MRKIVVAAIAVSLTTVSITASASADPSKDSKAQVSAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKPSAASIDAAKKAGVNNGNPLDAVQQ
Organism_Source Streptomyces avidinii
Functional_Classification Biotin-binding protein
Cellular_Localization Extracellular
Gene_Names
UniProt_ID P22629
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name 59-amino_acid_SBP_peptide
Peptide_Sequence CGGGGSTSGGSTSGGSTSGGGMDEKTTGWRGGHWWEGAGELEQLRARLEHHPQGQREP
Peptide_Length 58
Peptide_SMILES CSCC[C@H](NC(=O)CNC(=O)CNC(=O)CNC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CNC(=O)CNC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CNC(=O)CNC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CNC(=O)CNC(=O)CNC(=O)CNC(=O)[C@@H](N)CS)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N1CCC[C@H]1C(=O)O)[C@@H](C)O)[C@@H](C)O
Chemical_Modification
Cyclization_Method
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 5923.25
Aliphatic_Index 23.62069
Aromaticity 0.05172
Average_Rotatable_Bonds 3.36207
Charge_at_pH_7 -1.78047
Isoelectric_point 6.22610
Number_of_Hydrogen_Bond_Acceptors 90
Number_of_Hydrogen_Bond_Donors 98
Topological_Polar_Surface_Area 2724.37000
X_logP_energy -41.79162
Interaction Information
Affinity KD=7.67 nM
Affinity_Assay Surface Plasmon Resonance
PDB_ID
Type Affinity ligand
Structure
Reference Information
Document_Type Patent
Title STREPTAVIDIN MUTEIN EXHIBITING REVERSIBLE BINDING FOR BOTIN AND STREPTAVIDIN BINDING PEPTIDE TAGGED PROTEINS
Release_Year 2014
Patent_ID US20140378657A1