PPIPT00112
Target Protein Information
| Protein_Name | Homeobox protein engrailed-2 |
|---|---|
| Protein_Sequence | MEENDPKPGEAAAAVEGQRQPESSPGGGSGGGGGSSPGEADTGRRRALMLPAVLQAPGNHQHPHRITNFFIDNILRPEFGRRKDAGTCCAGAGGGRGGGAGGEGGASGAEGGGGAGGSEQLLGSGSREPRQNPPCAPGAGGPLPAAGSDSPGDGEGGSKTLSLHGGAKKGGDPGGPLDGSLKARGLGGGDLSVSSDSDSSQAGANLGAQPMLWPAWVYCTRYSDRPSSGPRSRKPKKKNPNKEDKRPRTAFTAEQLQRLKAEFQTNRYLTEQRRQSLAQELSLNESQIKIWFQNKRAKIKKATGNKNTLAVHLMAQGLYNHSTTAKEGKSDSE |
| Organism_Source | Homo sapiens |
| Functional_Classification | Homeobox transcription factor |
| Cellular_Localization | Nucleus |
| Gene_Names | EN2 |
| UniProt_ID | P19622 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Peptide 3 |
|---|---|
| Peptide_Sequence | PRSRKPKKKNPNKEDKRPRTAFTAEQLQR |
| Peptide_Length | 29 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 3506.03 |
|---|---|
| Aliphatic_Index | 20.34483 |
| Aromaticity | 0.03448 |
| Average_Rotatable_Bonds | 4.24138 |
| Charge_at_pH_7 | 8.00019 |
| Isoelectric_point | 12.05354 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 51 |
| Number_of_Hydrogen_Bond_Donors | 58 |
| Topological_Polar_Surface_Area | 1648.33000 |
| X_logP_energy | -20.42505 |
Interaction Information
| Affinity | KD=0.77 pM |
|---|---|
| Affinity_Assay | ELISA |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | IMMUNOGENIC FRAGMENT PEPTIDE OF EN2 PROTEIN OR ANTIBODY COMPOSITION SPECIFICALLY RECOGNIZING SAME |
| Release_Year | 2022 |
| Patent_ID | US20220106368A1 |