PPIPT00122

Target Protein Information
Protein_Name Immunoglobulin heavy constant alpha 1
Protein_Sequence ASPTSPKVFPLSLCSTQPDGNVVIACLVQGFFPQEPLSVTWSESGQGVTARNFPPSQDASGDLYTTSSQLTLPATQCLAGKSVTCHVKHYTNPSQDVTVPCPVPSTPPTPSPSTPPTPSPSCCHPRLSLHRPALEDLLLGSEANLTCTLTGLRDASGVTFTWTPSSGKSAVQGPPERDLCGCYSVSSVLPGCAEPWNHGKTFTCTAAYPESKTPLTATLSKSGNTFRPEVHLLPPPSEELALNELVTLTCLARGFSPKDVLVRWLQGSQELPREKYLTWASRQEPSQGTTTFAVTSILRVAAEDWKKGDTFSCMVGHEALPLAFTQKTIDRLADWQMPPPYVVLDLPQETLEEETPGANLWPTTITFLTLFLLSLFYSTALTVTSVRGPSGNREGPQY
Organism_Source Homo sapiens
Functional_Classification IgA heavy chain constant region
Cellular_Localization Extracellular
Gene_Names IGHA1
UniProt_ID P01876
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name SEQ ID NO:10
Peptide_Sequence HQVCLSYRGQPVCFST
Peptide_Length 16
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)O)[C@@H](C)O)C(C)C
Chemical_Modification None
Cyclization_Method Side chain-side chain cyclization; C4<->C13; disulfide bond
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1825.09
Aliphatic_Index 60.62500
Aromaticity 0.12500
Average_Rotatable_Bonds 3.43750
Charge_at_pH_7 0.96409
Isoelectric_point 8.23444
Number_of_Hydrogen_Bond_Acceptors 27
Number_of_Hydrogen_Bond_Donors 28
Topological_Polar_Surface_Area 748.71000
X_logP_energy -8.65793
Interaction Information
Affinity KD=0.699 mM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Patent
Title IgA-BINDING PEPTIDE AND PURIFICATION OF IgA THEREBY
Release_Year 2014
Patent_ID EP2787079A1