PPIPT00126
Target Protein Information
| Protein_Name | C-C chemokine receptor type 5 |
|---|---|
| Protein_Sequence | MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL |
| Organism_Source | Homo sapiens |
| Functional_Classification | G protein-coupled receptor |
| Cellular_Localization | Plasma membrane |
| Gene_Names | CCR5 |
| UniProt_ID | P51681 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Peptide_T_DAPTA |
|---|---|
| Peptide_Sequence | aSTTTNYT |
| Peptide_Length | 8 |
| Peptide_SMILES | C[C@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 473.48 |
|---|---|
| Aliphatic_Index | 40.00000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 2.20000 |
| Charge_at_pH_7 | -1.00157 |
| Isoelectric_point | 3.74999 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 8 |
| Number_of_Hydrogen_Bond_Donors | 7 |
| Topological_Polar_Surface_Area | 228.46000 |
| X_logP_energy | -3.26100 |
Interaction Information
| Affinity | IC50=0.32 nM |
|---|---|
| Affinity_Assay | Fluorescence Polarization |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | THERAPEUTIC PEPTIDES AND VACCINES |
| Release_Year | 2010 |
| Patent_ID | US20100184705A1 |