PPIPT00157
Target Protein Information
| Protein_Name | Melanocyte-stimulating hormone receptor |
|---|---|
| Protein_Sequence | MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFIAYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVLTCSW |
| Organism_Source | Homo sapiens |
| Functional_Classification | G protein-coupled receptor |
| Cellular_Localization | Plasma membrane |
| Gene_Names | MC1R |
| UniProt_ID | Q01726 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | MSH B |
|---|---|
| Peptide_Sequence | XHfRWXC |
| Peptide_Length | 7 |
| Peptide_SMILES | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CS)C(=O)O |
| Chemical_Modification | X1=norleucine; X6=2,3-diaminopropionic acid |
| Cyclization_Method | Side chain-side chain cyclization; X6<->C7; other bonds |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Acetyl |
| C-terminal_Modification | Amide |
| Amino_Acid_Distribution | |
|
|
|
Peptide Physicochemical
| Molecular_Weight | 861.98 |
|---|---|
| Aliphatic_Index | 0.00000 |
| Aromaticity | 0.28571 |
| Average_Rotatable_Bonds | 3.42857 |
| Charge_at_pH_7 | 1.02692 |
| Isoelectric_point | 8.55748 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 11 |
| Number_of_Hydrogen_Bond_Donors | 14 |
| Topological_Polar_Surface_Area | 344.29000 |
| X_logP_energy | -2.30453 |
Interaction Information
| Affinity | KD=2.5 nM |
|---|---|
| Affinity_Assay | Competitive binding assay |
| PDB_ID | None |
| Type | Agonist |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | CYCLIC PEPTIDE ANALOGS OF MELANOCORTIN AND AMANITIN AND METHODS OF MAKING SUCH |
| Release_Year | 2021 |
| Patent_ID | US20210024605A1 |