PPIPT00176

Target Protein Information
Protein_Name Erythropoietin receptor
Protein_Sequence MDHLGASLWPQVGSLCLLLAGAAWAPPPNLPDPKFESKAALLAARGPEELLCFTERLEDLVCFWEEAASAGVGPGNYSFSYQLEDEPWKLCRLHQAPTARGAVRFWCSLPTADTSSFVPLELRVTAASGAPRYHRVIHINEVVLLDAPVGLVARLADESGHVVLRWLPPPETPMTSHIRYEVDVSAGNGAGSVQRVEILEGRTECVLSNLRGRTRYTFAVRARMAEPSFGGFWSAWSEPVSLLTPSDLDPLILTLSLILVVILVLLTVLALLSHRRALKQKIWPGIPSPESEFEGLFTTHKGNFQLWLYQNDGCLWWSPCTPFTEDPPASLEVLSERCWGTMQAVEPGTDDEGPLLEPVGSEHAQDTYLVLDKWLLPRNPPSEDLPGPGGSVDIVAMDEGSEASSCSSALASKPSPEGASAASFEYTILDPSSQLLRPWTLCPELPPTPPHLKYLYLVVSDSGISTDYSSGDSQGAQGGLSDGPYSNPYENSLIPAAEPLPPSYVACS
Organism_Source Homo sapiens
Functional_Classification Class I cytokine receptor
Cellular_Localization Plasma membrane
Gene_Names EPOR
UniProt_ID P19235
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name EMP-1
Peptide_Sequence GGTYSCHFGPLTWVCKPQGG
Peptide_Length 20
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CS)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CNC(=O)CN)[C@@H](C)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)NCC(=O)O)C(C)C)[C@@H](C)O
Chemical_Modification None
Cyclization_Method Side chain-side chain cyclization; C6<->C15; disulfide bond
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2095.38
Aliphatic_Index 34.00000
Aromaticity 0.15000
Average_Rotatable_Bonds 3.00000
Charge_at_pH_7 0.96380
Isoelectric_point 8.23279
Number_of_Hydrogen_Bond_Acceptors 30
Number_of_Hydrogen_Bond_Donors 29
Topological_Polar_Surface_Area 793.14000
X_logP_energy -8.63020
Interaction Information
Affinity KD=200 nM
Affinity_Assay Surface Plasmon Resonance
PDB_ID 1ERN
Type Agonist
Structure
Reference Information
Document_Type Patent
Title EPO MIMETIC PEPTIDES AND FUSION PROTEINS
Release_Year 2007
Patent_ID US20070275871A1