PPIPT00185
Target Protein Information
| Protein_Name | Uncharacterized protein encoded by SND1-IT1 |
|---|---|
| Protein_Sequence | MSHHPHSLRNSCLIRMDLLYWQFTIYTITFCFSHLSGRLTLSAQHISHRPCLLSYSLLFWKVHHLFLEGFPCSPRLDEMSFHQFPQHPVHVSVVHLPIVYKGSMTQVSPH |
| Organism_Source | Homo sapiens |
| Functional_Classification | Uncharacterized protein |
| Cellular_Localization | Cytoplasm |
| Gene_Names | SND1-IT1 |
| UniProt_ID | Q9HBX3 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | MTDH_393-403 |
|---|---|
| Peptide_Sequence | DWNAPAEEWGN |
| Peptide_Length | 11 |
| Peptide_SMILES | C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1288.30 |
|---|---|
| Aliphatic_Index | 18.18182 |
| Aromaticity | 0.18182 |
| Average_Rotatable_Bonds | 3.27273 |
| Charge_at_pH_7 | -2.99802 |
| Isoelectric_point | 3.42471 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 17 |
| Number_of_Hydrogen_Bond_Donors | 18 |
| Topological_Polar_Surface_Area | 575.19000 |
| X_logP_energy | -5.17320 |
Interaction Information
| Affinity | KD=0.9 uM |
|---|---|
| Affinity_Assay | Fluorescence Polarization |
| PDB_ID | 4QMG |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | USE OF PEPTIDES THAT BLOCK METADHERIN-SND1 INTERACTION AS TREATMENT FOR CANCER |
| Release_Year | 2019 |
| Patent_ID | US20190336574A1 |