PPIPT00189

Target Protein Information
Protein_Name Vascular endothelial growth factor A, long form
Protein_Sequence MTDRQTDTAPSPSYHLLPGRRRTVDAAASRGQGPEPAPGGGVEGVGARGVALKLFVQLLGCSRFGGAVVRAGEAEPSGAARSASSGREEPQPEEGEEEEEKEEERGPQWRLGARKPGSWTGEAAVCADSAPAARAPQALARASGRGGRVARRGAEESGPPHSPSRRGSASRAGPGRASETMNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR
Organism_Source Homo sapiens
Functional_Classification Growth factor (VEGF family)
Cellular_Localization Extracellular
Gene_Names VEGFA
UniProt_ID P15692
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name TPP11
Peptide_Sequence HTPGNSKPTRTPRR
Peptide_Length 14
Peptide_SMILES C[C@@H](O)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1604.79
Aliphatic_Index 0.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 3.42857
Charge_at_pH_7 4.08859
Isoelectric_point 12.80743
Number_of_Hydrogen_Bond_Acceptors 25
Number_of_Hydrogen_Bond_Donors 28
Topological_Polar_Surface_Area 779.66000
X_logP_energy -12.25459
Interaction Information
Affinity KD=1.234 nM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Antagonist
Structure
Reference Information
Document_Type Patent
Title PHARMACEUTICAL COMPOSITION CONTAINING , AS ACTIVE INGREDIENT , FUSION PROTEIN IN WHICH TUMOR - PENETRATING PEPTIDE AND ANTIANGIOGENESIS AGENT ARE FUSED , FOR PREVENTING AND TREATING CANCER OR ANGIOGENESIS - RELATED DISEASES
Release_Year 2021
Patent_ID US20210253657A1