PPIPT00205
Target Protein Information
| Protein_Name | RAC-beta serine/threonine-protein kinase |
|---|---|
| Protein_Sequence | MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAECQLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPMDYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSASIRE |
| Organism_Source | Homo sapiens |
| Functional_Classification | Serine/threonine kinase |
| Cellular_Localization | Cytoplasm |
| Gene_Names | AKT2 |
| UniProt_ID | P31751 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Akt2_YYTYT |
|---|---|
| Peptide_Sequence | YYTYT |
| Peptide_Length | 5 |
| Peptide_SMILES | C[C@@H](O)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H](C)O)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | Side chain cyclization; N1<->T5; other bonds |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 709.75 |
|---|---|
| Aliphatic_Index | 0.00000 |
| Aromaticity | 0.60000 |
| Average_Rotatable_Bonds | 3.40000 |
| Charge_at_pH_7 | -0.00457 |
| Isoelectric_point | 6.08020 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 11 |
| Number_of_Hydrogen_Bond_Donors | 11 |
| Topological_Polar_Surface_Area | 280.87000 |
| X_logP_energy | -1.05600 |
Interaction Information
| Affinity | EC50=125 nM |
|---|---|
| Affinity_Assay | ELISA |
| PDB_ID | None |
| Type | Antagonist |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | CYCLIC PEPTIDES AS PROTEIN TARGETING AGENTS |
| Release_Year | 2021 |
| Patent_ID | US20210101936A1 |