PPIPT00206
Target Protein Information
| Protein_Name | L-lactate dehydrogenase |
|---|---|
| Protein_Sequence | MAPKAKIVLVGSGMIGGVMATLIVQKNLGDVVLFDIVKNMPHGKALDTSHTNVMAYSNCKVSGSNTYDDLAGADVVIVTAGFTKAPGKSDKEWNRDDLLPLNNKIMIEIGGHIKKNCPNAFIIVVTNPVDVMVQLLHQHSGVPKNKIIGLGGVLDTSRLKYYISQKLNVCPRDVNAHIVGAHGNKMVLLKRYITVGGIPLQEFINNKLISDAELEAIFDRTVNTALEIVNLHASPYVAPAAAIIEMAESYLKDLKKVLICSTLLEGQYGHSDIFGGTPVVLGANGVEQVIELQLNSEEKAKFDEAIAETKRMKALA |
| Organism_Source | Plasmodium falciparum (isolate CDC / Honduras) |
| Functional_Classification | Oxidoreductase (dehydrogenase) |
| Cellular_Localization | Cytoplasm |
| Gene_Names | None |
| UniProt_ID | Q27743 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | PfLDH_HWSAN |
|---|---|
| Peptide_Sequence | HWSAN |
| Peptide_Length | 5 |
| Peptide_SMILES | C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](CC(N)=O)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | Main chain-side chain cyclization; H1<->N5; other bonds |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 613.63 |
|---|---|
| Aliphatic_Index | 20.00000 |
| Aromaticity | 0.20000 |
| Average_Rotatable_Bonds | 3.20000 |
| Charge_at_pH_7 | 0.08889 |
| Isoelectric_point | 7.55032 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 9 |
| Number_of_Hydrogen_Bond_Donors | 10 |
| Topological_Polar_Surface_Area | 287.51000 |
| X_logP_energy | -3.08510 |
Interaction Information
| Affinity | EC50=2.57 nM |
|---|---|
| Affinity_Assay | ELISA |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | CYCLIC PEPTIDES AS PROTEIN TARGETING AGENTS |
| Release_Year | 2021 |
| Patent_ID | US20210101936A1 |