PPIPT00211

Target Protein Information
Protein_Name HBc antigen
Protein_Sequence MPSDFFPSIRDLLDTASALYREALESPEHCTPHHTALRQAILCWGELMNLATWVGSNLEDPASRELVVGYVNVNMGLKLRQLLWFHLSCLTFGRETVLEYLVSFGVWIRTPPAYRPQNAPILSTLPETTVIRRRGRSPRRRTPSPRRRRSQSPRRRRSQSREPQC
Organism_Source Hepatitis B virus
Functional_Classification HBc antigen
Cellular_Localization Cytoplasm
Gene_Names None
UniProt_ID Q2AC05
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name ADGTLLGRMKLA
Peptide_Sequence ADGTLLGRMKLA
Peptide_Length 12
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)N)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1245.50
Aliphatic_Index 114.16667
Aromaticity 0.00000
Average_Rotatable_Bonds 3.58333
Charge_at_pH_7 0.99813
Isoelectric_point 9.69502
Number_of_Hydrogen_Bond_Acceptors 18
Number_of_Hydrogen_Bond_Donors 19
Topological_Polar_Surface_Area 528.87000
X_logP_energy -4.82713
Interaction Information
Affinity KD=181 nM
Affinity_Assay phage display
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Patent
Title HBV core antigen particles with multiple immunogenic components attached via peptide ligands
Release_Year 2003
Patent_ID US20030198649A1