PPIPT00252

Target Protein Information
Protein_Name Genome polyprotein
Protein_Sequence MRCIGISNRDFVEGVSGGSWVDIVLEHGSCVTTMAKNKPTLDFELIKTEAKQPATLRKYCIEAKLTNTTTESRCPTQGEPSLNEEQDKRFVCKHSMVDRGWGNGCGLFGKGGIVTCAMFTCQKNMEGKIVQPENLEYTIVVTPHSGEEHAVGNDTGKHGKEIKITPQSSITEAELTGYGTVTMDCSPRTGLDFNEMVLLQMENKAWLVHRQWFLDLPLPWLPGADTQGSKLDQKETLVTFKNPHAKKQDVVVLGSQEGAMHTALTGATEIQMSSGNLLFTGHLKCRLRMDKLQLKGMSYSMCTGKFKVVEEIAETQHGTIVIRVQYEGDGSPCKIPLEIMDLDNRHVLGRLITVNPIVTEKDSPVNVEAEPPLGDSYIIIGVEPGQLKLNWFKKGSSIGQMFETTMIRAKRMAILGDTAWDFRSLGGVFTSIGKALHQVFGAIYGAAFSGVSWTMKILIGVIITWIGMNSRSTSLSVSLVLVGIVTLYLGVMVQA
Organism_Source Dengue virus type 2 (isolate Malaysia M2)
Functional_Classification Viral polyprotein
Cellular_Localization Extracellular
Gene_Names None
UniProt_ID P14338
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name PHB6
Peptide_Sequence PFNKGGKKKKp
Peptide_Length 11
Peptide_SMILES NCCCC[C@H](NC(=O)CNC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1228.50
Aliphatic_Index 0.00000
Aromaticity 0.09091
Average_Rotatable_Bonds 4.00000
Charge_at_pH_7 4.99651
Isoelectric_point 11.40291
Number_of_Hydrogen_Bond_Acceptors 18
Number_of_Hydrogen_Bond_Donors 17
Topological_Polar_Surface_Area 504.73000
X_logP_energy -4.79690
Interaction Information
Affinity IC50=33 mM
Affinity_Assay plaque formation assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Patent
Title BETA-HAIRPIN PEPTIDES HAVING ANTI-VIRAL PROPERTIES AGAINST THE DENGUE VIRUS
Release_Year 2017
Patent_ID EP3115056A2